1、At steady state, plasma BNP levels increase from baseline endogenous levels by approximately 3-fold to 6-fold with BNP infusion doses ranging from 0.01 to 0.03 mcg/kg/min.
2、The pharmacodynamic (PD) half-life of the onset and offset of the hemodynamic effect of BNP is longer than what the PK half-life of 18 minutes would predict.
3、After the 3-hour placebo-controlled period, patients receiving placebo crossed over to double-blinded active therapy with either BNP or nitroglycerin.
4、There was also no evidence of tachyphylaxis to the hemodynamic effects of BNP in the clinical trials.
5、In this trial, the nitroglycerin group provides a rough landmark using a familiar therapy and regimen.
1、当BNP以0.01到0.03mcg/kg/min的剂量静注，达到稳态水平时，血浆BNP水平从内在基础水平上升了大概3到6倍。
2、BNP血液动力学上的开始与结束的半衰期在药效学上比药动学上预算的18分钟的半衰期要长。
3、在3小时的安慰剂对照给药期后，进行交叉双盲实验，服用安慰剂的病人换用BNP或 nitroglycerin。
4、在临床试验中没有证据显示BNP的血液动力学有快速耐受现象。
5、在这次试验中，nitroglycerin对照组使用常用的剂量与用法只有一点显著之处。
不够专业，见笑了！
2、The pharmacodynamic (PD) half-life of the onset and offset of the hemodynamic effect of BNP is longer than what the PK half-life of 18 minutes would predict.
3、After the 3-hour placebo-controlled period, patients receiving placebo crossed over to double-blinded active therapy with either BNP or nitroglycerin.
4、There was also no evidence of tachyphylaxis to the hemodynamic effects of BNP in the clinical trials.
5、In this trial, the nitroglycerin group provides a rough landmark using a familiar therapy and regimen.
1、当BNP以0.01到0.03mcg/kg/min的剂量静注，达到稳态水平时，血浆BNP水平从内在基础水平上升了大概3到6倍。
2、BNP血液动力学上的开始与结束的半衰期在药效学上比药动学上预算的18分钟的半衰期要长。
3、在3小时的安慰剂对照给药期后，进行交叉双盲实验，服用安慰剂的病人换用BNP或 nitroglycerin。
4、在临床试验中没有证据显示BNP的血液动力学有快速耐受现象。
5、在这次试验中，nitroglycerin对照组使用常用的剂量与用法只有一点显著之处。
不够专业，见笑了！