大家好！我们正在做异维A酸胶丸，现在想增加溶出度，试验的溶出很低（用到有机溶剂25%），可是怎么也找不出解决的办法，急,请大家帮帮忙，若能解决，可以转移5分作为回报，先大家了。
不知参考过该工艺没有。Isotretinoin, a retinoid, is available as Accutane in 10-mg, 20-mg and 40-mg soft gelatin capsules for oral administration. Each capsule contains beeswax, butylated hydroxyanisole, edetate disodium, hydrogenated soybean oil flakes, hydrogenated vegetable oil, and soybean oil. Gelatin capsules contain glycerin and parabens (methyl and propyl), with the following dye systems: 10 mg - iron oxide (red) and titanium dioxide; 20 mg - FD&C Red No. 3, FD&C Blue No. 1, and titanium dioxide; 40 mg - FD&C Yellow No. 6, D&C Yellow No. 10, and titanium dioxide.另外想请问一下，05药典上并没有溶出这一项，为何要做溶出度，若要提高标准，可买到市场的对照样品，同法比较一下，看对照品溶出度如何。还有，溶出介质用的是一定浓度的醇溶液吗？
xinshidai提供的资料！我们的客户要仿制该品种，客户害怕很难批下来，所以客户要求定溶出。市场的对照样品，同法比较一下，溶出度很差，溶出介质用的是一定浓度的醇溶液。
不知参考过该工艺没有。Isotretinoin, a retinoid, is available as Accutane in 10-mg, 20-mg and 40-mg soft gelatin capsules for oral administration. Each capsule contains beeswax, butylated hydroxyanisole, edetate disodium, hydrogenated soybean oil flakes, hydrogenated vegetable oil, and soybean oil. Gelatin capsules contain glycerin and parabens (methyl and propyl), with the following dye systems: 10 mg - iron oxide (red) and titanium dioxide; 20 mg - FD&C Red No. 3, FD&C Blue No. 1, and titanium dioxide; 40 mg - FD&C Yellow No. 6, D&C Yellow No. 10, and titanium dioxide.另外想请问一下，05药典上并没有溶出这一项，为何要做溶出度，若要提高标准，可买到市场的对照样品，同法比较一下，看对照品溶出度如何。还有，溶出介质用的是一定浓度的醇溶液吗？
xinshidai提供的资料！我们的客户要仿制该品种，客户害怕很难批下来，所以客户要求定溶出。市场的对照样品，同法比较一下，溶出度很差，溶出介质用的是一定浓度的醇溶液。