最近我在SIGMA公司定了这个试剂,结果发现竟然没有溶解度,打电话给代理商也没结果,只能一个人死命搜索,毫无进展内,急啊!!!!!!!
请哪位好心人告诉我结果好吗?最好告诉我怎么去搜索(最好带有路径),谢谢啦!!
CCD上的数据 ，更详细的 在 SCIFINDER 上会有
RCB_CT,428229Entry Name: Tamoxifen, BAN, INN
Synonym: 2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine, 9CI. Kessar. Neophedan. Noltam. Nolvadex. Spectrila. Tamaxin. Tamofen. Tamoplex. Tamoxigenat. Valodex. Zemide. ICI 46474. NSC 180973. Many other
73229279,2770
Chapman Hall Number: BSS82-Q
Type of Compound Code: XA1950 XA1525
Molecular Formula: C26H29NO
Molecular Weight: 371.521
Accurate Mass: 371.224914
Percentage Composition: C 84.06%; H 7.87%; N 3.77%; O 4.31%
Biological Use/Importance: Antiestrogen; used in the treatment of breast cancer
Development Status: Marketed drug. Launched 1977
Partition Coefficient (Calculated): Log P 6.64 (calc)
Other Data: The active drug is prob. the 4-OH substd. deriv. Tradenames refer to the
RCB_CT,428230Variant: (E)-form
Synonym: ICI 47699
Chapman Hall Number: BSS83-R
CAS Registry Number: 13002-65-8
Molecular Formula: C26H29NO
Molecular Weight: 371.521
Accurate Mass: 371.224914
Percentage Composition: C 84.06%; H 7.87%; N 3.77%; O 4.31%
Physical Description: Cryst. (MeOH)
Melting Point: Mp 72-74
RTECS Accession Number: KR5919500
Aldrich: 28161-
RCB_CT,428231Derivative: 4''-Hydroxy
Chapman Hall Number: FQY17-I
CAS Registry Number: 174592-47-3
Extra CAS Registry Numbers: 68047-35-8
Molecular Formula: C26H29NO2
Molecular Weight: 387.521
Accurate Mass: 387.219829
Percentage Composition: C 80.59%; H 7.54%; N 3.61%; O 8.26%
Physical Description: Cryst. (EtOH)
Melting Point: Mp 155-157
RCB_CT,428232Variant: (Z)-form
Chapman Hall Number: BSS84-S
CAS Registry Number: 10540-29-1
Molecular Formula: C26H29NO
Molecular Weight: 371.521
Accurate Mass: 371.224914
Percentage Composition: C 84.06%; H 7.87%; N 3.77%; O 4.31%
Physical Description: Cryst. (petrol)
Melting Point: Mp 96-98
Other Data: Pharmacol. active isomer
Hazard Toxicity: Listed as a group 1 human carcinogen by IARC, despite reducing the risk of contralateral breast cancer
RTECS Accession Number: KR5919600
Sigma:
RCB_CT,428233Derivative: Citrate (1:1)
Synonym: Tamoxifen citrate, JAN, USAN. Duratamoxifen. Embion. Fentamox. Kessar. Noltam. Nolvadex. Oestrifen. Oncotam. Tamofen. Many other names
Chapman Hall Number: BSS85-T
CAS Registry Number: 54965-24-1
Melting Point: Mp 140-142
RTECS Accession Number: KH2387000
Sigma:
RCB_CT,428234Derivative: N-De-Me
Synonym: 2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N-methylethanamine, 9CI. Demethyltamoxifen
Chapman Hall Number: GYJ33-C
CAS Registry Number: 31750-48-8
Extra CAS Registry Numbers: 15917-65-4
Molecular Formula: C25H27NO
Molecular Weight: 357.494
Accurate Mass: 357.209264
Percentage Composition: C 83.99%; H 7.61%; N 3.92%; O 4.48%
Metabolism: Metab. of Tamoxifen
Physical Description: Cryst. (2-propanol) (as hydrochloride)
Melting Point: Mp 174-176
RCB_CT,428235Derivative: 4''-Hydroxy
Synonym: 4-[1-[4-[2-(Dimethylamino)ethoxy]phenyl]-2-phenyl-1-butenyl]phenol, 9CI. 4-Hydroxytamoxifen
Chapman Hall Number: FQY18-J
CAS Registry Number: 68047-06-3
Extra CAS Registry Numbers: 65213-48-1 68392-35-8
Molecular Formula: C26H29NO2
Molecular Weight: 387.521
Accurate Mass: 387.219829
Percentage Composition: C 80.59%; H 7.54%; N 3.61%; O 8.26%
Source/Synthesis: Metab. of Tamoxifen
Biological Use/Importance: Antioestrogen
Physical Description: Cryst. (EtOH)
Melting Point: Mp 140-143
Other Data: There is some confusion concerning the allocation of CAS nos. to this and the E-isomer above. This is the pharmacol. active enantiomer, corresponding to Z-
References:
Aldrich Library of 13C and 1H FT NMR Spectra, 1992, 2, 575B, (nmr)
Precigoux, G. et al., Acta Cryst. B, 1979, 35, 3070, (cryst struct)
Binart, N. et al., Biochem. Biophys. Res. Commun., 1979, 91, 812-818, (metab)
Robertson, D.W. et al., J.O.C., 1982, 47, 2387, (synth)
Miller, R.B. et al., J.O.C., 1985, 50, 2121, (synth, bibl)
Adam, H.K., Curr. Clin. Pract. Ser., 1986, 31, 83, (rev, anal)
Coe, P.L. et al., J.C.S. Perkin 1, 1986, 475, (synth)
Goldberg, I. et al., J. Pharm. Sci., 1987, 76, 259, (struct)
Al-Hassan, M., Synth. Commun., 1987, 17, 1247, (synth)
Legha, S.S., Ann. Intern. Med., 1988, 109, 219, (rev)
Buckley, M.M.-T. et al., Drugs, 1989, 37, 451, (rev)
Kikuta, C. et al., J. Pharm. Biomed. Anal., 1989, 4, 329-337, (Demethyltamoxifen, hplc) 2 1 2 下一页 尾页
请哪位好心人告诉我结果好吗?最好告诉我怎么去搜索(最好带有路径),谢谢啦!!
CCD上的数据 ，更详细的 在 SCIFINDER 上会有
RCB_CT,428229Entry Name: Tamoxifen, BAN, INN
Synonym: 2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine, 9CI. Kessar. Neophedan. Noltam. Nolvadex. Spectrila. Tamaxin. Tamofen. Tamoplex. Tamoxigenat. Valodex. Zemide. ICI 46474. NSC 180973. Many other
73229279,2770
Chapman Hall Number: BSS82-Q
Type of Compound Code: XA1950 XA1525
Molecular Formula: C26H29NO
Molecular Weight: 371.521
Accurate Mass: 371.224914
Percentage Composition: C 84.06%; H 7.87%; N 3.77%; O 4.31%
Biological Use/Importance: Antiestrogen; used in the treatment of breast cancer
Development Status: Marketed drug. Launched 1977
Partition Coefficient (Calculated): Log P 6.64 (calc)
Other Data: The active drug is prob. the 4-OH substd. deriv. Tradenames refer to the
RCB_CT,428230Variant: (E)-form
Synonym: ICI 47699
Chapman Hall Number: BSS83-R
CAS Registry Number: 13002-65-8
Molecular Formula: C26H29NO
Molecular Weight: 371.521
Accurate Mass: 371.224914
Percentage Composition: C 84.06%; H 7.87%; N 3.77%; O 4.31%
Physical Description: Cryst. (MeOH)
Melting Point: Mp 72-74
RTECS Accession Number: KR5919500
Aldrich: 28161-
RCB_CT,428231Derivative: 4''-Hydroxy
Chapman Hall Number: FQY17-I
CAS Registry Number: 174592-47-3
Extra CAS Registry Numbers: 68047-35-8
Molecular Formula: C26H29NO2
Molecular Weight: 387.521
Accurate Mass: 387.219829
Percentage Composition: C 80.59%; H 7.54%; N 3.61%; O 8.26%
Physical Description: Cryst. (EtOH)
Melting Point: Mp 155-157
RCB_CT,428232Variant: (Z)-form
Chapman Hall Number: BSS84-S
CAS Registry Number: 10540-29-1
Molecular Formula: C26H29NO
Molecular Weight: 371.521
Accurate Mass: 371.224914
Percentage Composition: C 84.06%; H 7.87%; N 3.77%; O 4.31%
Physical Description: Cryst. (petrol)
Melting Point: Mp 96-98
Other Data: Pharmacol. active isomer
Hazard Toxicity: Listed as a group 1 human carcinogen by IARC, despite reducing the risk of contralateral breast cancer
RTECS Accession Number: KR5919600
Sigma:
RCB_CT,428233Derivative: Citrate (1:1)
Synonym: Tamoxifen citrate, JAN, USAN. Duratamoxifen. Embion. Fentamox. Kessar. Noltam. Nolvadex. Oestrifen. Oncotam. Tamofen. Many other names
Chapman Hall Number: BSS85-T
CAS Registry Number: 54965-24-1
Melting Point: Mp 140-142
RTECS Accession Number: KH2387000
Sigma:
RCB_CT,428234Derivative: N-De-Me
Synonym: 2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N-methylethanamine, 9CI. Demethyltamoxifen
Chapman Hall Number: GYJ33-C
CAS Registry Number: 31750-48-8
Extra CAS Registry Numbers: 15917-65-4
Molecular Formula: C25H27NO
Molecular Weight: 357.494
Accurate Mass: 357.209264
Percentage Composition: C 83.99%; H 7.61%; N 3.92%; O 4.48%
Metabolism: Metab. of Tamoxifen
Physical Description: Cryst. (2-propanol) (as hydrochloride)
Melting Point: Mp 174-176
RCB_CT,428235Derivative: 4''-Hydroxy
Synonym: 4-[1-[4-[2-(Dimethylamino)ethoxy]phenyl]-2-phenyl-1-butenyl]phenol, 9CI. 4-Hydroxytamoxifen
Chapman Hall Number: FQY18-J
CAS Registry Number: 68047-06-3
Extra CAS Registry Numbers: 65213-48-1 68392-35-8
Molecular Formula: C26H29NO2
Molecular Weight: 387.521
Accurate Mass: 387.219829
Percentage Composition: C 80.59%; H 7.54%; N 3.61%; O 8.26%
Source/Synthesis: Metab. of Tamoxifen
Biological Use/Importance: Antioestrogen
Physical Description: Cryst. (EtOH)
Melting Point: Mp 140-143
Other Data: There is some confusion concerning the allocation of CAS nos. to this and the E-isomer above. This is the pharmacol. active enantiomer, corresponding to Z-
References:
Aldrich Library of 13C and 1H FT NMR Spectra, 1992, 2, 575B, (nmr)
Precigoux, G. et al., Acta Cryst. B, 1979, 35, 3070, (cryst struct)
Binart, N. et al., Biochem. Biophys. Res. Commun., 1979, 91, 812-818, (metab)
Robertson, D.W. et al., J.O.C., 1982, 47, 2387, (synth)
Miller, R.B. et al., J.O.C., 1985, 50, 2121, (synth, bibl)
Adam, H.K., Curr. Clin. Pract. Ser., 1986, 31, 83, (rev, anal)
Coe, P.L. et al., J.C.S. Perkin 1, 1986, 475, (synth)
Goldberg, I. et al., J. Pharm. Sci., 1987, 76, 259, (struct)
Al-Hassan, M., Synth. Commun., 1987, 17, 1247, (synth)
Legha, S.S., Ann. Intern. Med., 1988, 109, 219, (rev)
Buckley, M.M.-T. et al., Drugs, 1989, 37, 451, (rev)
Kikuta, C. et al., J. Pharm. Biomed. Anal., 1989, 4, 329-337, (Demethyltamoxifen, hplc) 2 1 2 下一页 尾页